The EU cosmetics regulation prohibits testing of cosmetic formulations on animals. To assure safety of new formulations non-animal tests like CALUX®, with their proven robustness and applicability to complex matrices, therefore are of key importance. BDS has been involved in several successful initiatives together with key industries and OECD to validate and demonstrate the applicability of such tests for cosmetics testing OECD approval was obtained for the (anti)estrogens test with ERalpha CALUX (TG-455) and for (anti)androgens with AR CALUX (TG 458), while the (anti)thyroid CALUX assay panel is under OECD review. Focus of in vitro testing of cosmetic formulations is on endocrine disruptors, via EATS testing.