BDS offers an extensive panel of high-throughput-compatible CALUX® reporter assays that enable biological effect identification and quantification and effect-based compound detection. Our assays allow for the sensitive and precise detection of specific biological effects at the cellular level. This can be used for the identification of fractions and compounds with beneficial health effects. However, context-dependent repression or overstimulation of these pathways form the key to toxic effects of chemicals. For this, context-dependent thresholds are defined.  In this way this panel can be used to predict major chemically-induced toxic effects such as sensitization, carcinogenesis and mutagenicity and, reproductive toxicity and endocrine disruption, related to health effects like birth- and fertility defects, cancer, metabolic syndrome and obesity.