Health beneficial activity screening
Our bioanalytical methods assess interference with cellular pathways that govern normal cell growth and differentiation. Some chemicals can interfere with these pathways. If this interference is strong and in an inappropriate uncontrolled context, like environmental or occupational exposure, this is unwanted and the basis of toxicity assessment. The main difference between health beneficial and toxic compounds is that the former compounds interact with these pathways in a more subtle manner, at lower therapeutic rather than toxic doses. Thus, these pathways often are equally important in the discovery of health beneficial compounds. An important asset of a druggable molecule is that it can enter the body and reach its target. Most CALUX assays are targeted by molecules with druggable properties, and by assessing entry into cells and major metabolic conversions already information on important barriers is obtained.