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A limited number of industrial chemicals is tested for their potential toxic properties, while even less is known about the vast number of natural chemicals. Nevertheless, we are mostly exposed to complex mixtures of all those compounds. Biological effects by mixtures are typically hard to predict from data on the limited number of well-characterized chemicals, since these cover only a part of the compounds actually present. Direct measurement of the total potency of toxic, or bioactive components in the mixture using CALUX® reporter assays solves these issues in the following ways
In the next sections several important applications of CALUX® methods are described in brief.