Beneficial health effects

The CALUX® reporter gene assays address very specific effects pathways, facilitating measurement and interpretation of results.  The pathways included are central in regulating cell functioning and are interesting targets for drugs and nutraceuticals. This includes ones that are relevant for obesity and metabolic syndrome (e.g. PPARs, dioxin- and steroid receptors), endocrine functioning (pathways e.g. related to sex steroid receptors), (anti)inflammatory and immune modulatory pathways (e.g. glucocorticoid receptors, NFkappaB signalling, sex steroid receptors and dioxin receptor), cancer (p21, p53 pathway, stress- and cytotoxicity pathways, angiogenesis, retinoid receptors, steroid receptors), and antioxidants/chemoprevention (nrf-2, retinoids), and others. With this high throughput screening (HTS) panel activities of interest can be rapidly identified in natural and environmental samples and in compound libraries for screening potential drug candidates.  Additional testing to validate these hits can be carried out in more physiological models. Furthermore, an assessment of stability and the effect of metabolic conversions can be made.  In combination with data on traditional use of the starting material, promising leads for improved formulations or new drug candidates can be identified.